Space charge modulation and ion current rectification of a cylindrical nanopore functionalized with polyelectrolyte...

Considering versatile potential applications of bioinspired membranes, we simulate the electrokinetic behavior of a cylindrical nanopore, surface modified by a polyelectrolyte (PE) layer. Taking account of the effect of electroosmotic flow and an additionally applied pH gradient, the influences of the strength of the pH gradient, the PE layer thickness, the length of the nanopore and its radius on its conductance and ion current rectification (ICR) performance are assessed. We show that if pH_U (the pH at the higher pH end of the nanopore) is fixed at 11 and pH_L (the pH at the lower pH end of the nanopore) varies from 3 to 11, the rectification factor R_f has a local maximum occurring in 6 < pH_L <8; the greater the magnitude of the applied potential bias |V| the smaller the pH_L at which the local maximum occurs. The influence of the PE layer thickness on the nanopore rectification performance is important only if 5 < pH_L <8, and the optimum performance is reached at a medium thick PE layer (ca. 3 nm). Possible mechanisms associated with the ion transport phenomenon under consideration are proposed and discussed in detail.