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Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
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Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Manisha H Shah1, Whitney S Goldner2, Al B Benson3

  • 11The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.

Journal of the National Comprehensive Cancer Network : JNCCN
|August 2, 2021
PubMed

Insights

The NCCN Guidelines offer updated strategies for diagnosing and managing neuroendocrine tumors (NETs) and adrenal gland tumors. They emphasize multidisciplinary care and genetic risk assessment for various tumor types.

Area of Science:

  • Oncology
  • Endocrinology
  • Genetics

Background:

  • Neuroendocrine tumors (NETs) and adrenal gland tumors require specialized, multidisciplinary management.
  • Current guidelines are essential for standardizing diagnosis and treatment protocols.
  • Genetic factors play a significant role in hereditary forms of these tumors.

Purpose of the Study:

  • To present the 2021 NCCN Clinical Practice Guidelines for Neuroendocrine and Adrenal Gland Tumors.
  • To detail principles of genetic risk assessment and counseling.
  • To provide recommendations for specific tumor types including NETs and adrenal tumors.

Main Methods:

  • Review of the 2021 NCCN Guidelines.
  • Focus on diagnostic criteria, staging, and treatment modalities.
  • Inclusion of genetic risk assessment and counseling principles.

Main Results:

  • Comprehensive guidelines for diagnosis and management of NETs, adrenal tumors, pheochromocytomas, paragangliomas, and multiple endocrine neoplasia.
  • Specific recommendations for well-differentiated grade 3 NETs, poorly differentiated neuroendocrine carcinomas, and adrenal tumors.
  • Emphasis on collaborative, multidisciplinary specialist involvement.

Conclusions:

  • The NCCN Guidelines provide a framework for optimal clinical decision-making in neuroendocrine and adrenal gland tumors.
  • Genetic risk assessment is a key component in managing hereditary forms of these conditions.
  • Adherence to these guidelines ensures comprehensive patient care through integrated specialist expertise.

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