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[Skin autoflora in patients with encephalomyelopolyradiculoneuritis with a protracted course]
Abstract:
The deep and superficial skin autoflora has been investigated in 57 patients with encephalomyelopolyradiculoneuritis (EMPRN) characterized by a protracted course. There was a tendency toward an increase in the total colonization of the skin, particularly in the zone of thin intestine projection onto the anterior abdominal wall with the appearance of colonies of microorganisms fermenting mannitol and splitting red blood cells in the amounts exceeding the normal range. These alterations were more marked in deep autoflora and they were evaluated as an indicator of depressed immunobiological reactivity of the body in patients with EMPRN. Skin autoflora in these patients was predominantly presented by a pathogenetic epidermal staphylococcus. The presence of this staphylococcus is considered as a factor of risk and the indicator that the development of staphylococcal infections is highly possible, which makes the "immunological disarmament" in patients with a protracted course of EMPRN even more pronounced.
Insights
Patients with encephalomyelopolyradiculoneuritis (EMPRN) show altered skin microflora, particularly in deep skin layers. This suggests impaired immune function and increased risk of staphylococcal infections in chronic EMPRN cases.
Area of Science:
- Microbiology
- Immunology
- Neurology
Context:
- Investigated skin autoflora in 57 patients with encephalomyelopolyradiculoneuritis (EMPRN).
- EMPRN cases were characterized by a protracted clinical course.
- Focused on both deep and superficial skin microflora.
Purpose:
- To analyze alterations in skin autoflora in EMPRN patients.
- To correlate skin microflora changes with immune status.
- To identify potential risk factors for infections in EMPRN.
Summary:
- Observed increased skin colonization, especially in the abdominal area, with mannitol-fermenting, blood-cell-lysing microorganisms.
- Deep skin autoflora showed more significant alterations.
- Pathogenetic Staphylococcus epidermidis was predominant, indicating high risk for staphylococcal infections.
Impact:
- Altered skin microflora, particularly deep autoflora changes, serves as an indicator of depressed immunobiological reactivity in EMPRN.
- The prevalence of Staphylococcus epidermidis highlights a significant risk factor for developing staphylococcal infections.
- These findings underscore the pronounced "immunological disarmament" in patients with chronic EMPRN, impacting disease management and prognosis.