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Diagnosis and management of cardiac allograft vasculopathy

Juan M Ortega-Legaspi1, Paco E Bravo2,3

  • 1Department of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Juan.OrtegaLegaspi@pennmedicine.upenn.edu.

Heart (British Cardiac Society)
|August 3, 2021
PubMed

Insights

Cardiac allograft vasculopathy (CAV) is a leading cause of death after heart transplantation. This review covers CAV

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Cardiac allograft vasculopathy (CAV) is a major cause of late mortality following heart transplantation.
  • Understanding CAV is critical for improving long-term survival rates in heart transplant recipients.

Purpose of the Study:

  • To review the current knowledge on the pathophysiology, detection, and treatment of cardiac allograft vasculopathy.
  • To summarize data on non-invasive imaging modalities for CAV screening and diagnosis.

Main Methods:

  • Literature review of current research on cardiac allograft vasculopathy.
  • Analysis of non-invasive imaging techniques for CAV detection.

Main Results:

  • Cardiac allograft vasculopathy presents a complex pathophysiology.
  • Non-invasive imaging modalities offer potential for screening and diagnosis of CAV.

Conclusions:

  • Improved understanding of CAV is essential for enhancing long-term outcomes in heart transplant patients.
  • Further research into CAV pathophysiology and advanced imaging is warranted.

Keywords:
cardiac imaging techniquesechocardiographyheart transplantationmagnetic resonance imagingpositron-emission tomography

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