Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acute appendicitis in the rabbit. An experimental study.

V M Pedersen¹, H P Olesen, A M Worning

¹Institute for Experimental Research in Surgery, University of Copenhagen, Denmark.

Acta Chirurgica Scandinavica

|October 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pleurodesis with polidocanol in pigs. An experimental study.

Chest·1994

Same author

Drug consumption among elderly--a four-year study.

Scandinavian journal of caring sciences·1994

Same author

Prevalence of infections and use of antibiotics among hospitalized patients in Mauritius. A nationwide survey for the planning of a national infection control programme.

The Journal of hospital infection·1993

Same author

Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen.

European journal of clinical investigation·1993

Same author

Fate of circulating amino-terminal propeptide of type III procollagen in conscious pigs.

The American journal of physiology·1993

Same author

Histomorphological evaluation of wound healing of rabbit oviduct after microsurgical reanastomosis with the use of autologous fibrin adhesive, human fibrin adhesive or poly-glycolic acid suture.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·1993

Same journal

Uretero-intestinal implantation according to Coffey.

Acta chirurgica Scandinavica·2010

Same journal

Closure of the bronchus in pneumonectomy and lobectomy.

Acta chirurgica Scandinavica·2010

Same journal

Tables for calculation of exact measurements of radiographed objects.

Acta chirurgica Scandinavica·2010

Same journal

Treatment of the congenital flat-foot.

Acta chirurgica Scandinavica·2010

Same journal

On the practical importance of the clinical determination of the basal metabolic rate in thyrotoxicosis.

Acta chirurgica Scandinavica·2010

Same journal

Splanchnectomy by megacolon congenitum.

Acta chirurgica Scandinavica·2010

See all related articles

Researchers developed a reliable rabbit model for acute appendicitis by ligating the vermiform appendix. This model effectively induces localized inflammation, aiding appendicitis research.

Area of Science:

Veterinary Medicine
Surgical Pathology
Experimental Surgery

Background:

Acute appendicitis is a common surgical emergency.
Developing reliable animal models is crucial for studying appendicitis pathogenesis and treatment.
Existing models may not accurately replicate localized inflammation.

Purpose of the Study:

To devise a reproducible experimental model of acute appendicitis in rabbits.
To establish a method that induces localized inflammation of the vermiform appendix.

Main Methods:

Initial experiments involved compression and proximal ligation of the vermiform appendix in rabbits.
A refined model using a firm ligature midway on the vermiform process was developed.
The final model was tested in a cohort of 15 rabbits.

Related Experiment Videos

Main Results:

The refined model reliably induced acute inflammation in a localized section of the appendix.
The ligature successfully created a reproducible inflammatory response.
The rest of the appendix remained largely unaffected, mimicking key aspects of human appendicitis.

Conclusions:

A firm ligature midway on the vermiform process provides a reliable experimental model for acute appendicitis.
This model allows for the study of localized appendiceal inflammation.
Further research can utilize this model to investigate appendicitis mechanisms and therapeutic interventions.