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Haemolytic anaemia induced by flutamide: a case report
1Department of Pharmacy, Ningbo City First Hospital, Ningbo, Zhejiang, China.
European Journal of Hospital Pharmacy : Science and Practice
|August 3, 2021
Summary
Flutamide can cause rare but fatal haemolytic anaemia. Promptly stopping flutamide and providing supportive care can reverse this serious side effect in patients with prostate cancer.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Flutamide is an anti-androgen medication used for prostate cancer treatment.
- Haemolytic anaemia is a rare but potentially fatal adverse effect of flutamide therapy.
Observation:
- An 88-year-old male patient with prostate carcinoma developed jaundice and haemolytic anaemia after 5 days of flutamide treatment.
- The patient's condition improved with cessation of flutamide, temporary adrenocortical hormone treatment, and blood transfusion.
Findings:
- Flutamide administration led to the development of severe haemolytic anaemia and jaundice.
- Discontinuation of flutamide and supportive care resulted in gradual recovery of blood indices and liver function.
Implications:
- Routine monitoring of complete blood counts is crucial for patients receiving flutamide.
- Early recognition and immediate discontinuation of flutamide are essential to manage flutamide-induced haemolytic anaemia.
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