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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Right ventricular dysfunction in rheumatic heart valve disease: A clinicopathological evaluation
Shantanu Pande1, Surendra K Agarwal1, Prabhat Tewari2
1Department of Cardiovascular and Thoracic Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
The National Medical Journal of India
|August 3, 2021
Summary
Right ventricle (RV) dysfunction in rheumatic heart disease (RHD) is linked to older age and higher RV systolic pressure. Earlier intervention may preserve RV function in these patients.
Area of Science:
- Cardiology
- Pathology
Background:
- Right ventricle (RV) dysfunction in rheumatic heart disease (RHD) is a significant indicator of poor prognosis.
- Understanding clinicopathological changes in the RV is crucial for managing RHD.
Purpose of the Study:
- To investigate the clinicopathological alterations in the right ventricle (RV) of patients diagnosed with rheumatic heart disease (RHD).
- To correlate RV dysfunction with specific pathological findings and clinical parameters in RHD patients.
Main Methods:
- RV dysfunction was defined by a myocardial performance index >0.4 on echocardiography.
- Patients with isolated severe mitral stenosis and normal left ventricular function were divided into two groups based on RV dysfunction.
- RV muscle biopsies were analyzed for apoptosis, fibrosis, and fat deposition.
Main Results:
- Patients with RV dysfunction were older and had higher RV systolic pressure (RVSP) and tricuspid regurgitation.
- No significant differences were found in RV fibrosis or apoptosis intensity between groups.
- Decreased interstitial fat deposition was observed in the RV of patients with RV dysfunction.
Conclusions:
- Older age and elevated RVSP are associated with RV dysfunction in RHD patients.
- Early intervention strategies may be beneficial for preserving RV function in RHD.
- Clinicopathological changes in the RV, particularly fat deposition, warrant further investigation in RHD.
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