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Risk of Myocarditis from COVID-19 Infection in People Under Age 20: A Population-Based Analysis

Mendel E Singer, Ira B Taub, David C Kaelber

    Medrxiv : the Preprint Server for Health Sciences
    |August 3, 2021
    PubMed
    Abstract

    Insights

    Young males infected with COVID-19 have a higher risk of myocarditis compared to vaccinated individuals. This study found myocarditis rates as high as 450 per million in males aged 12-17 following infection.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Vaccinology

    Background:

    • Myocarditis is a known side effect of mRNA COVID-19 vaccines, particularly in young males.
    • Limited data exists on myocarditis risk from COVID-19 infection itself, hindering complete risk-benefit analyses.

    Approach:

    • Utilized a de-identified electronic health record dataset from 48 U.S. healthcare organizations.
    • Analyzed patients aged 12-19 with a first COVID-19 diagnosis between April 2020 and March 2021, excluding those with prior cardiovascular conditions.
    • Assessed myocarditis incidence within 90 days post-diagnosis, stratifying by sex and age group.

    Key Points:

    • In males aged 12-17, the adjusted myocarditis rate was 450 per million (95% CI: 206-982).
    • Rates varied by age subgroup: 601 per million (12-15) and 561 per million (16-19).
    • Female cohorts showed lower rates: 213 per million (12-17), 235 per million (12-15), and 708 per million (16-19).

    Conclusions:

    • COVID-19 infection can lead to myocarditis at rates up to 450 per million in young males.
    • Young males infected with COVID-19 are up to six times more likely to develop myocarditis than vaccinated individuals.

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