Related Experiment Video
Updated: Oct 26, 2025
08:07
A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
2.5K
Chirality in peptide-based materials: From chirality effects to potential applications.
Zhonghui Chen1,2, Zhenguo Chi1, Yifeng Sun2
1Guangdong Engineering Technology Research Center for High performance Organic and Polymer Photoelectric Functional Films, State Key Laboratory of OEMT, School of Chemistry, Sun Yat-sen University, Guangzhou, China.
Chirality
|August 3, 2021
Summary
Chiral peptide materials offer tunable properties for novel applications. Understanding their chiral effects is key for advancements in chemistry and biomedicine.
Area of Science:
- Chirality in peptide-based materials science.
- Interdisciplinary applications in chemistry and biomedicine.
Background:
- Chirality is fundamental to biological processes and biomolecular interactions.
- Peptide-based materials can be engineered to exhibit specific physicochemical properties.
Purpose of the Study:
- To review recent research on chirality in peptide-based materials.
- To summarize chiral effects including recognition, amplification, and induction.
- To discuss applications and future directions.
Main Methods:
- Review of scientific literature on chiral peptide materials.
- Illustration of driving forces for chiral discrimination and supramolecular assembly.
- Presentation of implemented applications.
Main Results:
- Chiral effects in peptide materials are crucial for recognition, amplification, and induction.
- Chirality influences affinity interactions and supramolecular structures at multiple scales.
- Applications span bioseparation, cell incubation, drug development, and more.
Conclusions:
- Chiral peptide materials hold significant potential for innovative applications.
- Further research is needed to address challenges and explore new directions.
- Understanding chirality is vital for designing advanced materials and technologies.
Related Concept Videos
02:30Chirality in Nature
14.8K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
14.8K
02:25Chirality
27.3K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
27.3K
02:05Prochirality
4.2K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.2K
02:25Molecules with Multiple Chiral Centers
13.9K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
13.9K
02:30Chirality at Nitrogen, Phosphorus, and Sulfur
6.2K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
6.2K
02:24Properties of Enantiomers and Optical Activity
19.2K
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
19.2K