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Aqueous humour concentration of metoprolol after oral administration
1Department of Ophthalmology, Karolinska Institute/Huddinge University Hospital, Sweden.
Acta Ophthalmologica
|December 1, 1987
Abstract:
The concentration of the beta-adrenergic blocking agent metoprolol was determined in the blood plasma and aqueous humour of two groups of subjects after oral administration of the compound. One group (8 cases) had received a single divided dose of metoprolol, whilst the other group (7 cases) was receiving chronic therapy with the drug. There was a tendency towards a higher concentration of metoprolol in the aqueous humour as compared to the blood plasma in the chronic treatment group in contrast to the 'single' dose group.