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Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

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Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
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Dopamine D3 Receptors: From Bench to Bedside.

Xenia Gonda1,2, Frank I. Tarazi3

  • 1Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet Lapja = Official Journal of the Hungarian Association of Psychopharmacology
|August 3, 2021
PubMed
Summary

Dopamine D3 receptors are key targets for treating psychiatric and neurological disorders. Cariprazine, a D3-preferential drug, shows efficacy in schizophrenia, bipolar disorder, and potentially Parkinson's disease.

Keywords:
antipsychotic drugsbipolar disordercariprazinedopamine D3 receptorsParkinson’s diseaseschizophrenia

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Area of Science:

  • Neuropharmacology
  • Molecular Psychiatry

Background:

  • Dopamine D3 receptors are part of the D2-like family, with specific distribution in brain areas relevant to antipsychotic and Parkinson's disease medications.
  • Dopamine D3 receptors are implicated in various neurological and psychiatric conditions.

Purpose of the Study:

  • To explore the role of dopamine D3 receptors in psychiatric and neurological disorders.
  • To highlight the therapeutic potential of D3 receptor-targeting drugs, exemplified by cariprazine.

Main Methods:

  • Review of preclinical studies and clinical trials on cariprazine.
  • Analysis of D3 receptor pharmacology and its implications in disease states.

Main Results:

  • Cariprazine, a D2/D3 partial agonist with D3 preference, demonstrated clinical benefits in schizophrenia and bipolar disorder.
  • Cariprazine is the first antipsychotic approved for manic, mixed, and depressive bipolar I disorder episodes.
  • D3 receptor antagonism may alleviate levodopa-induced dyskinesia and psychosis in Parkinson's disease.

Conclusions:

  • Dopamine D3 receptors are promising therapeutic targets for psychiatric and neurological disorders.
  • Cariprazine exemplifies the successful development of D3 receptor-targeting agents.
  • Further research into D3 receptor modulation could lead to improved treatments for CNS disorders.