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Vitamin D receptor gene polymorphisms in atopy.

Laura Tamasauskiene1, Ieva Golubickaite2, Rasa Ugenskiene2

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Immunity, Inflammation and Disease
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Vitamin D may positively impact allergic diseases like asthma and atopic dermatitis, despite conflicting research on vitamin D levels and VDR gene polymorphisms in atopy. Further studies are needed to clarify these associations.

Keywords:
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Area of Science:

  • Allergy and immunology
  • Nutritional science
  • Genetics

Background:

  • Allergic conditions, including allergic asthma, rhinitis, and atopic dermatitis, are increasing globally, significantly impacting quality of life.
  • Vitamin D is increasingly recognized for its potential role in the risk and severity of allergic diseases.

Purpose of the Study:

  • To review and evaluate the role of vitamin D levels and vitamin D receptor (VDR) gene polymorphisms in atopy.
  • To synthesize current evidence on the association between vitamin D and allergic conditions.

Main Methods:

  • Systematic analysis of publications focusing on vitamin D levels and/or VDR gene polymorphisms in patients with allergic asthma, rhinitis, and atopic dermatitis.
  • Review of studies investigating the relationship between vitamin D, VDR gene variations, and the pathogenesis of atopic diseases.

Main Results:

  • Extensive research exists on vitamin D levels in atopy, but data on VDR gene polymorphisms and their correlation with vitamin D levels are less comprehensive.
  • Evidence suggests potential anti-inflammatory effects of vitamin D in allergic diseases, and some VDR polymorphisms may influence disease pathogenesis.
  • Findings across studies are often controversial, likely due to populational differences and methodological variations.

Conclusions:

  • While data on vitamin D levels and atopy remain debated, a growing body of evidence supports a beneficial impact of vitamin D on the risk and outcomes of allergic diseases, particularly atopic dermatitis and asthma.
  • Further research is warranted to elucidate the complex interplay between vitamin D, VDR gene polymorphisms, and allergic conditions.