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Updated: Oct 25, 2025
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Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
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Neglected Tropical Diseases and the Kidneys
Geraldo Silva Junior1, Nattachai Srisawat2,3,4,5,6, Phatadon Sirivongrangson2,3,4
1Public Health and Medical Sciences Graduate Programs, School of Medicine, University of Fortaleza, Fortaleza, Brazil.
Contributions to Nephrology
|August 3, 2021
Summary
Neglected tropical diseases (NTDs) significantly impact kidney health globally, affecting over a billion people. Early detection and novel biomarkers are crucial for managing NTD-related kidney disease, especially in young adults.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- Neglected tropical diseases (NTDs) represent a significant global health burden, frequently causing kidney damage.
- Over one billion individuals worldwide are affected by NTDs.
- NTDs are a potential cause of chronic kidney disease of unknown etiology, particularly impacting young, productive males.
Purpose of the Study:
- To review current knowledge on renal involvement in neglected tropical diseases.
- To summarize the epidemiology and impact of NTDs on kidney health.
- To highlight challenges and potential solutions for managing NTD-associated kidney disease.
Main Methods:
- Comprehensive literature review of NTDs and their renal manifestations.
- Analysis of epidemiological data concerning NTD prevalence and kidney disease.
- Synthesis of information on diagnostic challenges, treatment limitations, and prevention strategies.
Main Results:
- Kidney involvement is a common complication of many NTDs.
- NTDs contribute to the burden of chronic kidney disease, particularly in endemic regions.
- Novel kidney injury biomarkers show promise for early detection of renal damage.
Conclusions:
- Early detection of renal complications in NTDs is essential for improved patient outcomes.
- Development of novel therapeutic targets and drugs for NTDs is urgently needed.
- Integrated prevention strategies, including vector control and improved hygiene, are critical for mitigating NTD impact.
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