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Adrenal Gland Disorders01:27

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Updated: Oct 25, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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[New developments and perspectives in acromegaly].

Mario Detomas1, Miriam Reuter1, Timo Deutschbein1

  • 1Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik I, Lehrstuhl für Endokrinologie und Diabetologie, Würzburg; Medicover Oldenburg MVZ, Oldenburg.

Deutsche Medizinische Wochenschrift (1946)
|August 3, 2021
PubMed
Summary
This summary is machine-generated.

Early diagnosis of acromegaly, a growth hormone disorder, is crucial. Recent advancements in biochemical work-up, AI-driven diagnostics, and treatment options like oral somatostatin analogues improve patient outcomes.

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Area of Science:

  • Endocrinology
  • Oncology
  • Medical Diagnostics

Background:

  • Acromegaly results from excess growth hormone (GH) due to pituitary adenomas.
  • Delayed diagnosis increases morbidity and mortality.
  • Current screening uses insulin-like growth factor 1 (IGF-1) and GH suppression tests.

Purpose of the Study:

  • To review recent suggestions for biochemical diagnosis and comorbidity management in acromegaly.
  • To highlight emerging diagnostic tools and therapeutic strategies.
  • To address specific patient populations and challenges during the COVID-19 pandemic.

Main Methods:

  • Review of recent literature on acromegaly diagnosis and management.
  • Discussion of novel analytical tools, including AI for facial analysis.
  • Evaluation of updated imaging techniques (MRI/PET) and pharmaceutical options.

Main Results:

  • New approaches may enable earlier acromegaly diagnosis.
  • Surgical remission remains primary; repeated surgery may benefit from advanced imaging.
  • New oral somatostatin analogues and drug combinations offer therapeutic advancements.

Conclusions:

  • Earlier diagnosis and tailored management are key for acromegaly patients.
  • Innovations in diagnostics and therapeutics are improving treatment efficacy.
  • Special considerations are needed for vulnerable patient groups and during pandemics.