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Anti-infective Potential of Manzamine Alkaloids - A Review
Penta Ashok1, Faheem1, Banoth K Kumar1
1Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Rajasthan, Pilani-333031, India.
Background:
From time immemorial, natural products have been used for the treatment of various diseases. Various natural products, their semisynthetic derivatives, and synthetic analogs have been explored for their anti-infective properties. One such group of natural compounds that has been widely explored is manzamine alkaloids. Manzamine alkaloids are complex natural compounds consisting of a β-carboline nucleus attached to a pentacyclic ring system; they were first isolated from a marine sponge during the 1980s.
Objective:
This review aims to provide a critical overview on the anti-infective potential of manzamine alkaloids.
Methods:
A comprehensive and exhaustive review of the literature on manzamine alkaloids, and their isolation, anti-infective properties, and mechanism of action, is presented.
Results:
Various manzamine alkaloids have been isolated and have been found to exhibit potent antiinfective activities like antibacterial, antimalarial, antiviral, antifungal, antileishmanial, among others. These manzamine alkaloids exhibit their anti-infective activity by inhibiting targets like GSK-3β, MtSK.
Conclusion:
This present review along with structure-activity relationship study of manzamine alkaloids for their anti-infective activity will be useful for further development of semisynthetic manzamine analogs as potent anti-infective agents with better therapeutic potential and reduced toxicity.
