How to use the fractional exhaled nitric oxide test

Area of Science:

• Pulmonology
• Pediatric Medicine
• Biomarkers

Background:

• Fractional exhaled nitric oxide (FeNO) is an established, National Institute for Health and Care Excellence (NICE)-recommended biomarker.
• FeNO measurement provides an objective assessment of airway inflammation in asthma.
• Its utility is increasingly recognized in routine clinical practice.

Purpose of the Study:

• To provide general pediatricians with clinically relevant information on the uses of FeNO testing.
• To address practical challenges and considerations associated with performing FeNO measurements.
• To support the appropriate application of FeNO in pediatric asthma management.

Main Methods:

• Review of current literature and clinical guidelines regarding FeNO measurement.
• Formulation of practical questions addressing common issues faced by clinicians.
• Synthesis of evidence-based answers tailored for a general pediatric audience.

Main Results:

• FeNO testing is valuable for diagnosing and monitoring asthma, particularly eosinophilic airway inflammation.
• Practical considerations include patient technique, device calibration, and interpretation of results.
• Understanding potential confounding factors is crucial for accurate assessment.

Conclusions:

• FeNO measurement is a valuable, non-invasive tool for pediatric asthma management.
• Familiarity with its application and practicalities enhances its effective use.
• General pediatricians can confidently integrate FeNO testing into their clinical workflow.