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Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology.
María González-Esguevillas1, David F Fernández1, Juan A Rincón2
1Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
ACS Central Science
|August 4, 2021
Summary
A new microscale platform enables rapid optimization of photoredox catalysis for flow chemistry. This high-throughput experimentation (HTE) approach quickly identifies conditions directly transferable to scaled-up flow systems.
Area of Science:
- Organic Chemistry
- Chemical Engineering
- Catalysis
Background:
- Photoredox catalysis is vital for synthesizing complex molecules, widely used in pharmaceutical batch chemistry.
- Scaling up batch photoredox catalysis presents significant challenges, hindering its application in process chemistry.
- Existing methods for translating batch to flow conditions are often slow, inconvenient, and costly.
Purpose of the Study:
- To develop a rapid, convenient, and inexpensive method for optimizing photoredox catalysis for flow systems.
- To create a high-throughput experimentation (HTE) platform that directly translates to flow chemistry.
- To overcome the limitations of current batch-to-flow translation strategies.
Main Methods:
- Development of a microscale HTE platform designed to simulate flow-vessel pathways.
- Utilizing microscale reaction plates for simultaneous, rapid experimentation.
- Validating the HTE approach across various standard photoredox reactions.
Main Results:
- Successful identification of optimal reaction conditions using the HTE platform.
- Demonstrated accurate translation of optimized conditions to commercial flow reactors.
- Validated the platform's effectiveness for a range of photoredox transformations.
Conclusions:
- The developed HTE approach offers a general and efficient solution for optimizing photoredox catalysis in flow systems.
- This method significantly accelerates the identification of scalable flow protocols.
- The approach promises to broaden the application of photoredox catalysis in process chemistry.
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