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Health-related quality of life in meningioma
Sameah Haider1, Martin J B Taphoorn2,3, Katharine J Drummond4,5
1Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, Michigan, USA.
Background:
Meningiomas are the most common primary intracranial tumor in adults. Although frequently histologically benign, the clinical severity of a lesion may range from being asymptomatic to causing severe impairment of global function and well-being. The diversity of intracranial locations and clinical phenotypes poses a challenge when studying functional impairments, however, more recent attention to patient-reported outcomes and health-related quality of life (HRQOL) have helped to improve our understanding of how meningioma may impact a patient's life.
Methods:
Treatment strategies such as observation, surgery, radiation, or a combination thereof have been examined to ascertain their contributions to symptoms, physical and cognitive functioning, disability, and general aspects of daily functioning.
Results:
This review explores the multidimensional nature of HRQOL and how patients may be influenced by meningiomas and their treatment.
Conclusion:
Overall, treatment of symptomatic meningiomas is associated with improved HRQOL, cognitive functioning, and seizure control while tumor size, location, histologic grade, and epileptic burden are associated with worse HRQOL.
Insights
Treatment for symptomatic meningiomas improves health-related quality of life (HRQOL) and cognitive function. However, larger tumor size, specific locations, and higher tumor grade are linked to worse HRQOL in patients with meningiomas.
Area of Science:
- Neurology
- Oncology
- Public Health
Background:
- Meningiomas are the most common primary brain tumors in adults.
- While often benign, they can cause significant functional impairment and affect well-being.
- Patient-reported outcomes and health-related quality of life (HRQOL) are crucial for understanding meningioma's impact.
Purpose of the Study:
- To explore the multidimensional nature of HRQOL in meningioma patients.
- To understand how meningiomas and their treatments influence patient HRQOL.
- To identify factors associated with better or worse HRQOL outcomes.
Main Methods:
- Review of treatment strategies including observation, surgery, and radiation.
- Examination of contributions to symptoms, physical and cognitive functioning, and daily life.
- Analysis of patient-reported outcomes and health-related quality of life.
Main Results:
- Treatment of symptomatic meningiomas is associated with improved HRQOL.
- Improved cognitive functioning and seizure control are observed post-treatment.
- Tumor characteristics like size, location, and histologic grade correlate with worse HRQOL.
Conclusions:
- Symptomatic meningioma treatment positively impacts patient HRQOL and function.
- Specific tumor-related factors significantly influence the patient's quality of life.
- Understanding these factors is key for managing meningioma patient outcomes.
