Related Experiment Video
Updated: Oct 25, 2025
04:14
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
1.0K
Acrylamide induces a thyroid allostasis-adaptive response in prepubertal exposed rats
Viviane Matoso de Oliveira1, Fernanda Ivanski1, Isabela Medeiros de Oliveira1
1Laboratory of Reproductive Toxicology, Department of Medicine, State University of Central-West, Rua Simeao Camargo Varela de Sa, 03, 85040-080 Parana, Brazil.
Current Research in Toxicology
|August 4, 2021
Summary
Acrylamide (AA) in food disrupts the thyroid hormone system in rats, increasing thyroid hormones and altering gene expression in target tissues. Chronic AA exposure may contribute to thyroid dysfunction.
Area of Science:
- Endocrinology
- Toxicology
- Neuroscience
Background:
- Endocrine-disrupting chemicals (EDCs) can disrupt physiological homeostasis.
- Acrylamide (AA), found in cooked foods, is an electrophile linked to neurological defects and potential thyroid hormone reduction.
Purpose of the Study:
- To investigate if acrylamide (AA) affects the hypothalamus-pituitary-thyroid (HPT) axis.
- To assess repercussions in peripheral thyroid hormone (TH)-target systems.
Main Methods:
- Male Wistar rats were exposed to 2.5 or 5.0 mg AA/Kg/day during prepubertal development.
- Molecular markers in hypothalamus, pituitary, thyroid, heart, and liver were analyzed.
- Hormonal and lipid profiles were assessed in blood samples.
Main Results:
- AA exposure increased transcript expression of TH synthesis proteins and altered HPT axis homeostasis.
- Serum TH levels were elevated in AA-treated rats.
- Compensatory changes included increased Dio3 mRNA in the liver and decreased Mct8 transcript in the heart.
Conclusions:
- Acrylamide acts as an EDC affecting thyroid function and HPT axis homeostasis.
- Observed allostatic regulation suggests chronic AA exposure may contribute to thyroid dysfunction prevalence.
Keywords:
AA, acrylamideAcrylamideBW, body weightDIO1, iodothyronine deiodinase 1DIO2, iodothyronine deiodinase 2DIO3, iodothyronine deiodinase 3EDCs, endocrine-disrupting chemicalsEndocrine-disrupting chemicalsHDL, high-density lipoproteinsHPT, hypothalamus-pituitary-thyroid axisLDL, low lipoproteinsLOAEL, lowest Observed Adverse Effect LevelMCT-8, monocarboxylate transporter 8MYH6, myosin heavy chain 6NIS, sodium/iodide symporterNOAEL, no Observed Adverse Effect LevelPDS, pendrinPND, postnatal dayRfD, reference doseT3, triiodothyronineT4, thyroxineTDI, tolerable daily intakeTH, thyroid hormonesTHRA1, thyroid hormone receptor alpha 1THRB2, thyroid hormone receptor beta 2TPO, thyroid peroxidaseTRH, thyrotropin releasing hormone hormoneTRHR, thyrotropin releasing hormone receptorTSH, thyroid hormone receptorTSH, thyrotropinThyroidThyroid hormone metabolism
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
5.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.9K
01:18Functions of Thyroid Hormones
3.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.8K