Related Experiment Video
Updated: Jul 27, 2026
Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
Published on: June 15, 2011
Multiple myeloma with cardiac involvement accompanied by partial superior vena cava obstruction: A case report and
Shuzhen Wang1, Ruohan Zhao1, Kunyue Tan1
1Department of Cardiology, Cardiovascular Institute of Chengdu, Chengdu Third People's Hospital, The Affiliated Hospital of Southwest Jiaotong, Chengdu, China.
Insights
Extramedullary involvement of the endocardium is a rare complication of multiple myeloma. Surgical resection of cardiac masses can effectively alleviate symptoms in affected patients.
Area of Science:
- Cardiology
- Oncology
- Hematology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Extracardiac involvement is uncommon in multiple myeloma.
- Endocardial involvement presents a rare but serious complication.
Observation:
- A 57-year-old male with multiple myeloma presented with right atrial masses and superior vena cava obstruction.
- Echocardiography identified multiple solid masses.
- Surgical resection of the masses was performed.
Findings:
- The resected masses were identified as extramedullary plasmablastic transformation with endocardial involvement.
- A literature review identified 12 cases of cardiac space-occupying lesions in multiple myeloma patients over 10 years.
- Echocardiography is crucial for diagnosing and monitoring cardiac involvement in multiple myeloma.
Implications:
- Surgical resection of cardiac masses can provide symptomatic relief.
- Early diagnosis and management are vital for patients with multiple myeloma and cardiac involvement.
- This case highlights the importance of considering rare complications in multiple myeloma management.
Abstract:
Multiple myeloma is a malignant proliferative disorder of plasma cells. Extramedullary involvement of the endocardium is rare in multiple myeloma. Here, we reported a 57-year-old male, once was diagnosed with multiple myeloma. The echocardiography reveled multiple solid masses in the right atrium, along with partial obstruction of superior vena cava. The mass resection alleviated the edema of upper limbs and identified the mass as extramedullary plasmablastic transformation and endocardial involvement. We also conducted a literature review and summary analysis of space-occupying lesions in the heart in 12 patients with multiple myeloma (including the current case) in the last 10 years. Echocardiography is the preferred radiologic examination method for diagnosis and follow-up in multiple myeloma with cardiac involvement, and surgical resection is effective for alleviating symptoms.
Related Concept Videos
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
01:29Cardiomyopathy V: Interprofessional Care
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management