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Updated: Oct 25, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
[Polypharmacy in elderly patients]
R J van Marum1,2, J S Burgers3, M L Bouvy4
1Amsterdam UMC, locatie VUmc, Amsterdam Public Health research institute, afd. Huisartsgeneeskunde en Ouderengeneeskunde, Amsterdam(tevens: Jeroen Bosch Ziekenhuis, afd. Geriatrie en afd. Klinische Farmacologie, 's-Hertogenbosch).
Abstract:
Polypharmacy is increasing with age. With increasing numbers of medication, the risk of the use of potential inappropriate medication is also increasing. In this article we suggest using the WHO-6-step for rational prescribing. We also describe methods and instruments (amongst others: the systemic tool to reduce inappropriate prescribing)physicians can use in assessing the appropriateness of the medication already used by their patients. Finally we describe how, based on recent Dutch guidelines, deprescribing can be done.
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