Metagenomic Sequencing for Direct Identification of Candida auris Colonization

Candida auris is an emerging multidrug-resistant yeast that is associated with skin colonization and deadly bloodstream infections, especially in ventilator skilled nursing facilities. An ongoing question is how this organism colonizes the skin of these patients and whether the skin microbiome provides a measure of colonization resistance against C. auris. Now, Huang et al. (X. Huang, R. M. Welsh, C. Deming, D. M. Proctor, et al., mSphere 6:e00287-21, 2021, https://doi.org/10.1128/mSphere.00287-21) demonstrate a method for shotgun metagenomic analysis of the skin to generate a profile of fungal colonization that is highly correlative with culture-based methods. These methods are likely to assist in the diagnosis of C. auris and the identification of microbiome-associated risk factors that predict invasive disease.