State-of-the-art Hepatocellular Carcinoma Biomarker Detection by Biosensor Technology-a Review

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Molecular Diagnostics

Background:

• Biosensors are increasingly vital for self-diagnostic technologies.
• Analyzing biomarkers with biosensor systems offers significant advantages in time, cost, and practicality.
• Early detection of challenging diseases like hepatocellular carcinoma (HCC) is crucial.

Purpose of the Study:

• To compile and review biosensor applications for hepatocellular carcinoma (HCC) biomarker determination.
• To highlight the potential of various biosensor platforms in clinical diagnostics.

Main Methods:

• Review of electrochemical, optical, and piezoelectric biosensors.
• Analysis of biosensors designed for protein, DNA, RNA, and cell detection.
• Examination of biorecognition elements including antibodies, DNA, aptamers, and nanocomposites.

Main Results:

• Various biosensor types are effective for detecting HCC biomarkers.
• Biosensors can be designed using diverse recognition elements like antibodies and aptamers.
• These technologies facilitate the analysis of biomarkers at varying concentrations.

Conclusions:

• Biosensors represent a powerful tool for the early detection and diagnosis of hepatocellular carcinoma.
• The development of advanced biosensor designs based on novel materials and recognition elements is ongoing.
• Biosensor technology holds significant promise for improving clinical studies and patient outcomes in HCC management.