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Five MDM4 gene polymorphisms on cancer risk: An updated systematic review and meta-analysis

Yaxuan Wang1, Zhan Yang1, Xueliang Chang1

  • 1Department of Urology, 71213The Second Hospital of Hebei Medical University, China.

The International Journal of Biological Markers
|August 4, 2021
PubMed
Abstract

Insights

This study investigated MDM4 gene polymorphisms and cancer risk. Certain MDM4 variations (rs1380576 and rs4245739) show a reduced cancer risk in Asian populations and for breast cancer.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • The MDM4 gene, also known as MDMX or HDMX, plays a crucial role in cell cycle regulation and tumor suppression.
  • Polymorphisms in the MDM4 gene have been investigated for their potential association with various cancer types.
  • Understanding these genetic variations can contribute to personalized cancer risk assessment.

Purpose of the Study:

  • To comprehensively evaluate the association between five specific MDM4 gene polymorphisms (rs1380576, rs1563828, rs10900598, rs11801299, and rs4245739) and cancer susceptibility.
  • To identify specific MDM4 polymorphisms that may influence an individual's risk of developing cancer.
  • To provide insights into the genetic factors contributing to cancer development.

Main Methods:

  • A systematic literature search was performed across PubMed, Medline, and Web of Science for candidate gene studies published before February 27, 2021.
  • Keywords included MDM4 (and its aliases), polymorphism (and related terms), and cancer (and related terms).
  • Meta-regression, subgroup analysis, and sensitivity analysis were employed to explore potential sources of heterogeneity.

Main Results:

  • The meta-analysis included 15 studies with 21,365 cancer cases and 29,280 controls.
  • The MDM4 rs1380576 polymorphism was associated with a decreased cancer risk in the Asian population.
  • The MDM4 rs4245739 polymorphism showed an inverse association with cancer risk in Asians and specifically with breast cancer susceptibility.

Conclusions:

  • The MDM4 rs1380576 polymorphism is negatively associated with cancer risk among Asians.
  • The MDM4 rs4245739 polymorphism is inversely associated with cancer risk in the Asian population and breast cancer susceptibility.
  • These findings highlight the potential role of specific MDM4 genetic variations in cancer predisposition.
Keywords:
MDM4Mouse double minute 4 homologcancermeta-analysissingle-nucleotide polymorphism

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