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Erectile dysfunction in hyperuricemia: A prevalence meta-analysis and meta-regression study.
Maria Totaro1, Sotirios Dimarakis1, Chiara Castellini1
1Andrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Andrology
|August 4, 2021
Summary
A significant percentage of men with hyperuricemia experience erectile dysfunction (ED). This condition is more prevalent in those with type 2 diabetes mellitus, suggesting hyperuricemia may indicate broader metabolic issues affecting sexual health.
Area of Science:
- Urology
- Endocrinology
- Metabolic Syndrome
Background:
- The association between hyperuricemia and erectile dysfunction (ED) requires further clarification.
- Hyperuricemia is linked to various metabolic disturbances, potentially impacting vascular and erectile function.
Purpose of the Study:
- To determine the pooled prevalence of ED in men with hyperuricemic disorders.
- To identify factors associated with ED in this population.
Main Methods:
- A systematic literature search was conducted across major databases (Medline, Scopus, Cochrane Library).
- Data from 8 studies involving 85,406 men were pooled using random-effects models.
- Publication bias was assessed using funnel plots, and meta-regression analyzed covariates.
Main Results:
- The overall pooled prevalence of ED among hyperuricemic men was 33%.
- Type 2 diabetes mellitus was significantly associated with a higher prevalence of ED (β=0.08, p=0.025).
- Subgroup analyses showed ED prevalence ranging from 4% in studies with low type 2 diabetes mellitus to 50% in those with high type 2 diabetes mellitus.
Conclusions:
- A substantial proportion of men with hyperuricemia suffer from ED.
- Hyperuricemia may serve as a marker for systemic dysmetabolic disorders that impair erectile function, particularly in the context of type 2 diabetes mellitus.
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