Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CosSIF: Cosine similarity-based image filtering to overcome low inter-class variation in synthetic medical image datasets.

Computers in biology and medicine·2024
Same author

Regular Splitting Graph Network for 3D Human Pose Estimation.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2023
Same author

Quantifying imbalanced classification methods for leukemia detection.

Computers in biology and medicine·2022
Same author

Knowledge distillation approach towards melanoma detection.

Computers in biology and medicine·2022
Same author

Automatic segmentation of blood cells from microscopic slides: A comparative analysis.

Tissue & cell·2021
Same author

MoNuSAC2020: A Multi-Organ Nuclei Segmentation and Classification Challenge.

IEEE transactions on medical imaging·2021
Same journal

A computational model of chemically- and mechanically-induced thrombus formation in cerebral aneurysms.

Computers in biology and medicine·2026
Same journal

An improved catch fish optimization based deep learning model for Parkinson disease classification using EEG signal.

Computers in biology and medicine·2026
Same journal

Assessing the robustness of evaluation metrics for synthetic ECG signal quality.

Computers in biology and medicine·2026
Same journal

Integrating stemness and epithelial-mesenchymal transition signatures with machine learning identifies RUNX1 as a therapeutic vulnerability in colorectal cancer.

Computers in biology and medicine·2026
Same journal

Differential regional textural attributes of tongue in normal and acidity patients in the light of traditional Chinese medicine.

Computers in biology and medicine·2026
Same journal

SC-MSDNet: Spatial-consistent multi-view self-distillation for retinal OCT classification.

Computers in biology and medicine·2026
See all related articles

Related Experiment Video

Updated: Oct 25, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
04:48

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

3.1K

Sharp U-Net: Depthwise convolutional network for biomedical image segmentation.

Hasib Zunair1, A Ben Hamza1

  • 1Concordia Institute for Information Systems Engineering, Concordia University, Montreal, QC, Canada.

Computers in Biology and Medicine
|August 4, 2021
PubMed
Summary
This summary is machine-generated.

Sharp U-Net enhances biomedical image segmentation by using a novel sharpening filter to improve feature fusion and reduce segmentation errors. This depthwise encoder-decoder network achieves state-of-the-art results without additional parameters.

Keywords:
Fully convolutional networkSemantic segmentationSharpening filterSkip connectionsU-Net

More Related Videos

Objectification of Tongue Diagnosis in Traditional Medicine, Data Analysis, and Study Application
05:56

Objectification of Tongue Diagnosis in Traditional Medicine, Data Analysis, and Study Application

Published on: April 14, 2023

2.8K
Swin-PSAxialNet: An Efficient Multi-Organ Segmentation Technique
04:48

Swin-PSAxialNet: An Efficient Multi-Organ Segmentation Technique

Published on: July 5, 2024

584

Related Experiment Videos

Last Updated: Oct 25, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
04:48

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

3.1K
Objectification of Tongue Diagnosis in Traditional Medicine, Data Analysis, and Study Application
05:56

Objectification of Tongue Diagnosis in Traditional Medicine, Data Analysis, and Study Application

Published on: April 14, 2023

2.8K
Swin-PSAxialNet: An Efficient Multi-Organ Segmentation Technique
04:48

Swin-PSAxialNet: An Efficient Multi-Organ Segmentation Technique

Published on: July 5, 2024

584

Area of Science:

  • Medical Imaging
  • Computer Vision
  • Deep Learning

Background:

  • U-Net is a popular fully convolutional network for biomedical image segmentation.
  • Traditional U-Net architectures suffer from blurred feature maps and inaccurate segmentation due to direct merging of dissimilar features via skip connections.

Purpose of the Study:

  • To introduce Sharp U-Net, an improved fully convolutional network architecture for biomedical image segmentation.
  • To address the limitations of U-Net, specifically blurred feature maps and over/under-segmentation.

Main Methods:

  • Developed an end-to-end depthwise encoder-decoder fully convolutional network named Sharp U-Net.
  • Incorporated a novel sharpening filter layer that applies depthwise convolution with a sharpening kernel to encoder feature maps before merging with decoder features.
  • This layer fuses semantically similar features and smooths artifacts early in training.

Main Results:

  • Sharp U-Net consistently outperformed or matched state-of-the-art baselines across six diverse datasets for both binary and multi-class segmentation.
  • The proposed model achieved superior performance without introducing any additional learnable parameters.
  • Sharp U-Net demonstrated effectiveness compared to baselines with significantly more learnable parameters.

Conclusions:

  • Sharp U-Net offers a simple yet effective solution for improving biomedical image segmentation accuracy.
  • The novel sharpening filter mechanism enhances feature fusion and reduces segmentation inaccuracies.
  • This architecture provides a parameter-efficient and high-performing alternative to existing U-Net models.