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Lung-brain axis.

Ousman Bajinka1,2,3, Lucette Simbilyabo4, Yurong Tan1,2

  • 1Department of Medical Microbiology, Central South University, Changsha, Hunan Provinces, China.

Critical Reviews in Microbiology
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Summary
This summary is machine-generated.

The lung-brain axis links lung microbes to neurological conditions. Understanding this bidirectional communication is key for treating respiratory infections and neurodegenerative diseases.

Keywords:
HPA axisLung-brain axisdysbiosismetabolic changesmicrobiome medicineneurodegenerative diseases

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Area of Science:

  • Biomedical Research
  • Microbiome Medicine
  • Neuroscience

Background:

  • The human microbiome's role in health is increasingly recognized.
  • The lung-brain axis, linking pulmonary microbes to neurological disorders, is an emerging area of study.
  • Existing research highlights the need for a comprehensive analysis of the lung-brain axis.

Purpose of the Study:

  • To review current English literature on the lung-brain axis.
  • To identify prospects and research gaps in understanding pulmonary microbe-neurological disorder connections.
  • To propose an interdisciplinary approach for future research.

Main Methods:

  • Comprehensive literature review of "lung-brain axis" research.
  • Analysis of emerging studies and existing human data.
  • Exploration of conceptual research approaches in physiology and pathophysiology.

Main Results:

  • The review synthesizes current knowledge on the lung-brain axis.
  • Identifies the need for integrated, interdisciplinary research.
  • Highlights the potential of multimodal studies including animal models.

Conclusions:

  • Understanding the lung-brain axis is crucial for developing treatments for lung-induced neurodegenerative diseases.
  • Knowledge of host-microbiome communication in the lungs can aid in treating respiratory infections and neurological effects.
  • An interdisciplinary, multimodal approach is recommended for future lung-brain axis research.