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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

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Pharmacological Basis of Breast Cancer Resistance to Therapies - An Overview

Stefania Crucitta1, Federico Cucchiara1, Francesca Sciandra1

  • 1Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy.

Anti-Cancer Agents in Medicinal Chemistry
|August 5, 2021
PubMed

Insights

Breast cancer (BC) is a complex disease with varied treatment responses. Understanding molecular resistance mechanisms is key to improving patient outcomes with targeted therapies and immunotherapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer (BC) exhibits molecular heterogeneity, leading to diverse patient responses to treatment.
  • Key altered cellular processes in BC include uncontrolled cell-cycle, signaling pathway activation, and DNA-repair defects, contributing to therapeutic resistance.

Purpose of the Study:

  • To review the genetic and molecular mechanisms of resistance to breast cancer treatments.
  • To discuss the clinical implications of these resistance mechanisms.

Main Methods:

  • Literature review focusing on genetic and molecular aspects of breast cancer resistance.
  • Analysis of current therapeutic strategies, including targeted therapies and immunotherapy.
  • Examination of the role of biomarkers and molecular profiling.

Main Results:

  • Molecular profiling aids in personalized treatment decisions for breast cancer.
  • Understanding resistance mechanisms is crucial for developing new therapeutic strategies.
  • Novel biomarkers and therapeutic options are essential to overcome treatment resistance.

Conclusions:

  • Personalized treatment strategies informed by molecular profiling are vital for managing breast cancer.
  • Continued research into resistance mechanisms will enhance the efficacy of targeted therapies and immunotherapies for breast cancer patients.
Keywords:
Breast cancerchemotherapyhormone receptorshuman epidermal growth factor receptor 2immunotherapymechanisms of resistancetarget therapytriple-negative breast cancer

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