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Updated: Oct 25, 2025

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Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial

Roman E Kalinin1, Igor A Suchkov1, Nina D Mzhavanadze1

  • 1Department of Cardiovascular, Endovascular, Operative Surgery, and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russia.

Vascular Specialist International
|August 5, 2021
PubMed

Insights

Patients with advanced peripheral arterial disease (PAD) show increased clotting factors. Revascularization procedures further elevate these factors, linking them to complications like graft thrombosis and myocardial infarction.

Area of Science:

  • Vascular Medicine
  • Hematology
  • Cardiovascular Research

Background:

  • Peripheral arterial disease (PAD) is a significant cardiovascular condition.
  • Endothelial dysfunction and hypercoagulability are implicated in PAD progression and complications.

Purpose of the Study:

  • To assess the impact of intrinsic coagulation factors and endothelial dysfunction markers on PAD complications.
  • To investigate the relationship between specific coagulation factors (FVIII, FIX, FXI) and hemostatic markers (vWF, sEPCR, PAI-1) with PAD outcomes.

Main Methods:

  • Prospective study of 120 PAD patients (Fontaine stages 2b-3) undergoing various treatments.
  • Measurement of coagulation factors (FVIII, FIX, FXI) and endothelial hemostatic markers (vWF, sEPCR, PAI-1).

Main Results:

  • Open and endovascular revascularization significantly increased FVIII, FIX, and FXI activities.
  • Increased FVIII activity correlated with bypass graft thrombosis.
  • Elevated vWF activity was associated with myocardial infarction and restenosis.
  • Increased PAI-1 levels linked to PAD progression in conservative treatment group.

Conclusions:

  • Advanced PAD patients exhibit a hypercoagulable state.
  • Revascularization exacerbates hypercoagulability.
  • Coagulation factors and endothelial markers are predictive of PAD complications like thrombosis, MI, restenosis, and progression.
Abstract

Keywords:
Endovascular proceduresHemostasisPeripheral arterial diseaseThrombosisVascular endothelium

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