Related Experiment Videos
Primary intracranial malignant lymphomas with particular reference to their pathogenesis.
Acta Pathologica Japonica
|November 1, 1977
Summary
Primary central nervous system lymphomas are distinct entities, not just reticulum cell sarcomas. Diagnostic criteria include perivascular cuffing and starry-sky appearance, suggesting the brain can be a primary site for these lymphomas.
Area of Science:
- Neuropathology
- Oncology
- Central Nervous System Neoplasms
Background:
- Malignant lymphomas primarily originating in the central nervous system (CNS) are rare.
- Distinguishing these CNS lymphomas from other brain tumors can be challenging.
Purpose of the Study:
- To propose a reclassification of primary CNS lymphomas.
- To highlight key diagnostic criteria for these tumors.
- To discuss the potential pathogenesis of primary intracranial lymphomas.
Main Methods:
- Review of 6 cases of primary CNS malignant lymphomas over 6 years.
- Analysis of diagnostic criteria including silver impregnation for perivascular cuffing, starry-sky appearance, and imprint cytology.
- Histological comparison with extracerebral malignant lymphomas.
Main Results:
- Identified reliable diagnostic criteria: perivascular cuffing, starry-sky appearance, and specific cytological features.
- Observed histological similarity to extracerebral lymphomas.
- Proposed reclassifying these as primary CNS lymphomas, not reticulum cell sarcoma-microglioma.
Conclusions:
- Primary malignant lymphomas of the CNS are a distinct diagnostic category.
- The brain should be considered a potential primary site for lymphomas, similar to visceral sites.
- The pathogenesis may involve multipotential stem cells within the brain, as hypothesized by Feigin.