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Biologic characterization of canine melanoma cell lines
L G Wolfe1, J L Oliver, B B Smith
1Department of Pathology and Parasitology, College of Veterinary Medicine, Auburn University, AL 36849.
American Journal of Veterinary Research
|November 1, 1987
Abstract:
Eight canine melanoma cell lines were established from tissues from 6 dogs with spontaneous primary or metastatic melanomas. Cell lines were characterized for morphologic features and growth patterns on plastic, pigmentation, ultrastructure, cloning efficiency in soft agar, and tumorigenicity in nude mice. Biologic properties of cell lines were distinct and preserved during 40 to 120 passages in vitro. All cell lines were clonogenic and tumorigenic.