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Common anti-COVID-19 drugs and their anticipated interaction with anesthetic agents

Shagun B Shah1, Uma Hariharan2, Rajiv Chawla1

  • 1Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, India.

Journal of Anaesthesiology, Clinical Pharmacology
|August 5, 2021
PubMed

Keywords:
Anesthetic drugsCOVID-19azithromycindexamethasonefavipiravirhydroxychloroquineivermectinnitazoxanideremdesivirritonavirtocilizumab

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
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