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Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus
Fang Liu1, Yaru Wang1, Qiang Zhao2
1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, 272067, People's Republic of China.
Objective:
This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM).
Methods:
This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS).
Results:
The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P<0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was <4.17 mg/dl (β 0.12,95% CI -0.04, 0.28; P=0.121) and decreased when UA was >4.17 mg/dl (β -0.38,95% CI -0.64, -0.12; P=0.004).
Conclusion:
This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.
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