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Prospects for Epigenetic Targeted Therapies of Bone and Soft-Tissue Sarcomas

Jun Wang1,2, Arielle Elkrief2, Wei Guo1

  • 1Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.

Sarcoma
|August 5, 2021
PubMed

Insights

Epigenetic drugs offer a promising new approach for treating bone and soft-tissue sarcomas. This review covers their clinical use and ongoing trials for these aggressive cancers.

Area of Science:

  • Oncology
  • Epigenetics
  • Cancer Biology

Background:

  • Alterations in chromatin structure and modifications are implicated in the development of bone and soft-tissue sarcomas.
  • Epigenetic regulators are crucial in the pathogenesis of these aggressive cancers.
  • Targeted therapies have transformed cancer treatment paradigms.

Purpose of the Study:

  • To review the clinical application of epigenetic drugs in bone and soft-tissue sarcomas.
  • To provide an overview of current clinical trials investigating epigenetic therapies for these cancers.
  • To highlight the potential of epigenetic drugs as a novel targeted therapy strategy.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of ongoing clinical trials for epigenetic therapies in bone and soft-tissue sarcomas.
  • Synthesis of current knowledge on epigenetic drug utilization.

Main Results:

  • Epigenetic drugs represent a rational targeted therapy approach for bone and soft-tissue sarcomas.
  • Several epigenetic drugs are under investigation in clinical trials for these malignancies.
  • The review consolidates information on the current landscape of epigenetic therapies.

Conclusions:

  • Epigenetic therapies hold significant promise for the treatment of bone and soft-tissue sarcomas.
  • Further clinical evaluation is essential to establish the efficacy and safety of these agents.
  • Targeting epigenetic mechanisms offers a novel avenue for managing aggressive sarcomas.

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