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Updated: Oct 25, 2025

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Recent development and applications of semipinacol rearrangement reactions
Xiao-Ming Zhang1, Bao-Sheng Li2, Shao-Hua Wang1
1State Key Laboratory of Applied Organic Chemistry and School of Pharmacy, Lanzhou University Lanzhou 730000 P. R. China.
Abstract:
As has been well-recognized, semipinacol rearrangement functions as an exceptionally useful methodology in the synthesis of β-functionalized ketones, creation of quaternary carbon centers, and construction of challenging carbocycles. Due to their versatile utilities in organic synthesis, development of novel rearrangement reactions has been a vibrant topic that continues to shape the research field. Recent breakthroughs in novel electrophiles, tandem processes, and enantioselective catalytic transformations further enrich the toolbox of this chemistry and spur the strategic applications of this methodology in natural product synthesis. These achievements will be discussed in this minireview.
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