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Updated: Oct 25, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Allylic alcohol synthesis by Ni-catalyzed direct and selective coupling of alkynes and methanol
Herong Chen1, Zhijun Zhou1, Wangqing Kong1
1The Institute for Advanced Studies (IAS), Wuhan University Wuhan Hubei 430072 P. R. China wqkong@whu.edu.cn.
Abstract:
Methanol is an abundant and renewable chemical raw material, but its use as a C1 source in C-C bond coupling reactions still constitutes a big challenge, and the known methods are limited to the use of expensive and noble metal catalysts such as Ru, Rh and Ir. We herein report nickel-catalyzed direct coupling of alkynes and methanol, providing direct access to valuable allylic alcohols in good yields and excellent chemo- and regioselectivity. The approach features a broad substrate scope and high atom-, step- and redox-economy. Moreover, this method was successfully extended to the synthesis of [5,6]-bicyclic hemiacetals through a cascade cyclization reaction of alkynones and methanol.
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