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By-design molecular architectures via alkyne metathesis
Shaofeng Huang1, Zepeng Lei1, Yinghua Jin1
1Department of Chemistry, University of Colorado Boulder 80309 USA wei.zhang@colorado.edu.
Chemical Science
|August 5, 2021
Summary
Shape-persistent organic molecules are built using Dynamic Covalent Chemistry (DCvC). Ethynylene linkages formed via alkyne metathesis enable the creation of stable macrocycles and molecular cages with diverse applications.
Area of Science:
- Organic Chemistry
- Supramolecular Chemistry
- Materials Science
Background:
- Shape-persistent purely organic molecular architectures are of significant research interest.
- Dynamic Covalent Chemistry (DCvC) provides efficient synthetic routes for constructing these architectures.
- Ethynylene linkages, formed via alkyne metathesis, offer desirable stability, linearity, and rigidity.
Purpose of the Study:
- To review synthetic strategies for discrete molecular architectures containing ethynylene linkages.
- To highlight the role of alkyne metathesis as a key synthetic step.
- To discuss the applications of these ethynylene-containing architectures.
Main Methods:
- Focus on alkyne metathesis for the formation of ethynylene linkages.
- Review of synthetic strategies for macrocycles and molecular cages.
- Discussion of catalyst development for alkyne metathesis.
Main Results:
- Exploration of historical challenges and advancements in alkyne metathesis.
- Presentation of novel macrocycle and molecular cage structures.
- Summary of the diverse applications of these molecular architectures.
Conclusions:
- Alkyne metathesis is a powerful tool for synthesizing shape-persistent organic architectures.
- Ethynylene linkages contribute to the stability and functionality of macrocycles and cages.
- Future outlook and remaining challenges in the field are discussed.
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