Related Experiment Video

Updated: Oct 25, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.2K

Ductal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study

Emma Brouwer1, Ronny Knol1,2, Nathan D Hahurij3

  • 1Division of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, Netherlands.

Frontiers in Pediatrics
|August 5, 2021
PubMed

Insights

This pilot study found a non-significant correlation between ductus arteriosus (DA) flow ratio and oxygenation in preterm infants shortly after birth. Further research is needed to confirm if DA flow ratio can predict neonatal outcomes.

Area of Science:

  • Neonatal Physiology
  • Cardiovascular Adaptation
  • Perinatal Medicine

Background:

  • Cardiovascular transition after birth involves changes in ductus arteriosus (DA) pressure gradients.
  • The DA flow ratio (R-L/L-R) may indicate transitional status in neonates.
  • Predicting neonatal outcomes in preterm infants is crucial.

Purpose of the Study:

  • To investigate the correlation between DA flow ratio and oxygenation parameters in preterm infants at 1 hour post-birth.
  • To assess the relationship between DA flow ratio and FiO2, SpO2, and the SpO2/FiO2 ratio.
  • To compare DA flow ratios between infants managed with physiological-based cord clamping (PBCC) and time-based cord clamping (TBCC).

Main Methods:

  • Echocardiography was used to measure DA flow in preterm infants (<32 weeks gestational age).
  • DA flow ratio was calculated and correlated with oxygenation indices (FiO2, SpO2, SF ratio).
  • Infants were grouped based on cord clamping method (PBCC vs. TBCC) for comparative analysis.

Main Results:

  • Analysis included 16 preterm infants (median GA 29 weeks).
  • A moderate, though non-significant, correlation was observed between DA flow ratio and SpO2 (CC -0.415), FiO2 (CC 0.384), and SF ratio (CC -0.356).
  • No significant differences in DA flow measurements were found between PBCC and TBCC groups.

Conclusions:

  • This pilot study suggests a potential, but not statistically significant, positive correlation between DA flow ratio and oxygenation parameters in preterm infants at 1 hour of life.
  • The DA flow ratio's utility in predicting neonatal outcomes requires further investigation with larger sample sizes.
  • Cord clamping methods (PBCC vs. TBCC) did not appear to influence DA flow measurements in this cohort.

Keywords:
ductus arteriosusechocardiogaphyneonatal transitionpreterm birthumbilical cord clamping

More Related Videos

Transcutaneous Microcirculatory Imaging in Preterm Neonates06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.4K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.9K

Related Concept Videos

General Characteristics of Pipe Flow I01:22

General Characteristics of Pipe Flow I

Pipe flow refers to the movement of fluids within fully enclosed conduits, typically cylindrical in shape, such as water pipes or hydraulic hoses. These conduits are designed to withstand high-pressure gradients that drive fluid movement, contrasting with open-channel flows, where gravity is the primary driving force. Rectangular conduits, like air conditioning and heating ducts, generally operate at lower pressures and are less suited for high-pressure applications.
The classification of fluid...
1.4K
Laminar Flow: Problem Solving01:24

Laminar Flow: Problem Solving

Laminar flow occurs when a fluid moves smoothly in parallel layers with minimal mixing and turbulence. In fluid mechanics, ensuring laminar flow within a pipe is essential for precise control of flow characteristics, especially in engineering applications. The key factor in determining whether flow remains laminar is the Reynolds number, a dimensionless quantity that depends on the fluid's velocity, density, viscosity, and the pipe's diameter. A Reynolds number of 2100 or lower...
287
Laminar Flow01:27

Laminar Flow

Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
1.5K
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
1.1K
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.7K
Pipe Flowrate Measurement01:28

Pipe Flowrate Measurement

In pipe flow measurement, orifice, nozzle, and Venturi meters are commonly used to determine fluid flowrates by constricting the flow area, which increases fluid velocity and reduces pressure. This pressure difference, governed by Bernoulli's principle and adjusted for real-world conditions, is essential for calculating flowrate. Each meter type is suited to specific applications based on accuracy, efficiency, and compatibility with various flow conditions.
The orifice meter is a simple,...
870