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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
308
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
123
Altered States of Awareness01:06

Altered States of Awareness

655
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
655
An Overview of Psychoactive Drugs01:28

An Overview of Psychoactive Drugs

356
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
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Engineering Safer Psychedelics for Treating Addiction.

Jamie Peters1,2, David E Olson3,4,5

  • 1Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

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|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Non-hallucinogenic compounds like tabernanthalog (TBG) show promise for treating addiction by repairing brain circuitry. These psychoplastogens may offer therapeutic benefits without the psychedelic experience, advancing new addiction treatments.

Keywords:
PsychedelicTBGaddictionalcohol use disorderibogaineneuroplasticityneuropsychiatric disorderopioid use disorderpsychoplastogensubstance use disordertabernanthalog

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Addiction Research

Background:

  • Addiction is characterized by maladaptive neuroplasticity, strengthening reward pathways and weakening executive control.
  • Psychedelics show therapeutic potential for addiction, often linked to profound insights.
  • Psychedelics are potent psychoplastogens, capable of rapidly altering brain circuitry.

Purpose of the Study:

  • To explore the therapeutic potential of non-hallucinogenic psychoplastogens for addiction.
  • To investigate if therapeutic effects in addiction treatment require hallucinogenic properties.
  • To discuss the implications of tabernanthalog (TBG) for addiction therapeutics.

Main Methods:

  • Preclinical models relevant to alcohol and opioid addiction were utilized.
  • The effects of tabernanthalog (TBG), a non-hallucinogenic psychoplastogen, were assessed.
  • The study discusses the potential of TBG and related compounds.

Main Results:

  • Tabernanthalog (TBG) demonstrated long-lasting therapeutic effects in preclinical addiction models.
  • Evidence suggests that repairing neural circuitry may be key to therapeutic benefits.
  • Non-hallucinogenic psychoplastogens offer a potential alternative to traditional psychedelics.

Conclusions:

  • Hallucinations may not be essential for all psychedelic-based addiction therapies.
  • Non-hallucinogenic psychoplastogens like TBG represent a promising new avenue for addiction treatment development.
  • Further research is warranted to advance TBG and similar compounds as addiction therapeutics.