Alzheimer's and Consciousness: How Much Subjectivity Is Objective?

Area of Science:

• Neuroscience
• Cognitive Psychology
• Pathology

Background:

• Alzheimer Disease (AD) is characterized by cognitive decline.
• Understanding the nature of altered reality perception in AD is crucial.
• The role of microtubules in AD pathogenesis is under investigation.

Purpose of the Study:

• To propose a novel perspective on how Alzheimer Disease affects the awareness of reality.
• To investigate the shift from objective to subjective reality perception in AD patients.
• To explore the potential link between microtubule dysfunction and early AD symptoms.

Main Methods:

• Conceptual analysis of reality representation in AD.
• Theoretical framework linking subjective/objective awareness shifts.
• Hypothesizing microtubule involvement in early AD pathogenesis.

Main Results:

• Patients with increasing Alzheimer Disease symptoms demonstrate a change in the awareness of subjective versus objective reality.
• This shift results in a more internal perception of reality.
• The proposed paradigm suggests early signs of impairment originate from microtubule alterations.

Conclusions:

• Alzheimer Disease involves a fundamental change in how patients perceive reality, shifting towards internal experiences.
• Investigating this paradigm shift may reveal early biomarkers for memory and self-awareness deficits.
• Microtubule dynamics are a potential key factor in the early stages of Alzheimer Disease.