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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
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Cranial Bones: Superior and Posterior View01:14

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Oct 25, 2025

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
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Craniocervical abnormalities in osteogenesis imperfecta type V.

K Ludwig1,2, C Seiltgens1,2, A Ibba1,2

  • 1Shriners Hospitals for Children, 1003 Boulevard Decarie, Montreal, QC, H4A 0A9, Canada.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|August 5, 2021
PubMed
Summary

Craniocervical abnormalities, including basilar invagination and cervical kyphosis, are observed in Osteogenesis Imperfecta (OI) type V. Early screening with X-rays is crucial for detecting these potentially severe neurological conditions in OI type V patients.

Keywords:
Basilar invaginationCervical spineKyphosisOsteogenesis imperfect

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Area of Science:

  • Orthopedics
  • Neurology
  • Genetics

Background:

  • Craniocervical abnormalities in Osteogenesis Imperfecta (OI) can lead to significant neurological issues.
  • While cranial base abnormalities in OI are documented, data on OI type V and its specific clinical impact are limited.

Purpose of the Study:

  • To investigate the prevalence and characteristics of craniocervical abnormalities in patients with Osteogenesis Imperfecta type V.
  • To understand the association between these abnormalities and clinical sequelae in OI type V.

Main Methods:

  • Retrospective case series analysis of patients diagnosed with craniocervical abnormalities and OI type V.
  • Inclusion of genetically confirmed OI type V patients with available clinical and radiological data.

Main Results:

  • Craniocervical abnormalities were identified in 19% (7/37) of OI type V patients.
  • Common abnormalities included basilar invagination and cervical kyphosis; 3 patients required surgery for spinal cord or brainstem compression.
  • Neurological examination findings were not always significant, highlighting the role of screening.

Conclusions:

  • Osteogenesis Imperfecta type V can present with diverse craniocervical abnormalities, including cervical vertebrae dysplasia.
  • Regular screening using lateral skull and cervical spine X-rays is recommended for all OI type V patients throughout childhood and into adulthood.