A dosing algorithm for individualized radioiodine treatment of cats with hyperthyroidism

Radioiodine (¹³¹ I) is the treatment of choice for hyperthyroidism in cats, but current ¹³¹ I-dosing protocols can induce iatrogenic hypothyroidism and expose azotemia.

To develop a cat-specific algorithm to calculate the lowest ¹³¹ I dose to resolve hyperthyroidism, while minimizing risk of iatrogenic hypothyroidism and subsequent azotemia.

One thousand and four hundred hyperthyroid cats treated with ¹³¹ I.

Prospective case series (before-and-after study). All cats had serum concentrations of thyroxine (T₄ ), triiodothyronine (T₃ ), and thyroid-stimulating hormone (TSH) measured (off methimazole ≥1 week). Using thyroid scintigraphy, each cat's thyroid volume and percent uptake of ^99m Tc-pertechnatate (TcTU) were determined. An initial ¹³¹ I dose was calculated by averaging dose scores for T₄ /T₃ concentrations, thyroid volume, and TcTU; 80% of that composite dose was administered. Twenty-four hours later, percent ¹³¹ I uptake was measured, and additional ¹³¹ I administered, as needed, to deliver an adequate radiation dose to the thyroid tumor(s). Serum concentrations of T₄ , TSH, and creatinine were determined 6 to 12 months later.

The median calculated ¹³¹ I dose was 1.9 mCi (range, 1.0-10.6 mCi); 1380 cats required additional ¹³¹ I administration on day 2. Of the cats, 1047 (74.8%) became euthyroid, 57 (4.1%) became overtly hypothyroid, 240 (17.1%) became subclinically hypothyroid, and 56 (4%) remained hyperthyroid. More overtly (71.9%) and subclinically (39.6%) hypothyroid cats developed azotemia than euthyroid cats (14.2%; P < .0001).

Our algorithm for calculating individual ¹³¹ I doses resulted in cure rates similar to historical treatment rates, despite much lower ¹³¹ I doses. This algorithm appears to lower prevalence of both ¹³¹ I-induced overt hypothyroidism and azotemia.