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Updated: Oct 25, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Synthesis, enantioseparation, and absolute configuration assignment of iminoflavans by chiral high-performance liquid
Mohamed Nadjib Rebizi1, Khaled Sekkoum1, Antonella Petri2
1Bioactive Molecules and Chiral Separation Laboratory, University Tahri Mohamed of Bechar, Bechar, Algeria.
Abstract:
Four racemic iminoflavan derivatives were synthesized by simple condensation at C-4 position of flavanone. All new compounds were characterized by using ultraviolet-visible, infrared, and nuclear magnetic resonance spectroscopic techniques. A chiral chromatographic analysis of racemic mixtures was performed by direct chiral high-performance liquid chromatography using Chiralcel® OD-H as chiral stationary phase, and online-coupled with electronic circular dichroism detector. The correlation of experimental electronic circular dichroism traces with quantum chemical electronic circular dichroism calculations run with time-dependent density functional theory made it possible to elucidate the absolute configuration for each enantiomer, and to establish the elution order.
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