Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

1.7K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
1.7K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solid-State 3D Electrochemiluminescence Platform: Depth-Tuned Ru Complexes Positioning for Label-Free High-Resolution Imaging.

ACS omega·2026
Same author

Edge-Grafted Polyarginine Functionalization of Graphene Nanocarriers Maintains Noncovalent Aromatic Drug Loading.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same author

Sustainable biopolymers as protective coatings against indoor corrosion of bronze: A comparison among alginate, carboxymethyl cellulose, chitosan and pectin.

International journal of biological macromolecules·2026
Same author

Gold Nanorod-Radiopharmaceutical Conjugates for Nuclear Medicine Theranostics: A Methodological and Multiscale Perspective.

International journal of molecular sciences·2026
Same author

Describing the use of ruxolitinib for the treatment of myelofibrosis: a plain language summary of the ROMEI early study results.

Future oncology (London, England)·2026
Same author

Enhancing Non-small Cell Lung Cancer Susceptibility to Anti-PD-1/PD-L1 Therapy through PD-L1 Ligand-Ir(III) Complex Conjugates.

Cancer communications (London, England)·2026

Related Experiment Video

Updated: Oct 25, 2025

Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices
11:06

Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices

Published on: July 8, 2016

10.6K

Driving Organic Nanocrystals Dissolution Through Electrochemistry.

Gianlorenzo Bussetti1, Claudia Filoni1, Andrea Li Bassi2

  • 1Department of Physics, Politecnico di Milano, p.za Leonardo da Vinci 32, Milano, 20133 Milano, Italy.

Chemistryopen
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Electrochemistry drives the dissolution of both free-base and metal porphyrin nanocrystals. Electrochemical atomic force microscopy (EC-AFM) reveals distinct dissolution behaviors based on applied potential.

Keywords:
ToF-SIMScrystal dissolutionelectrochemistryetch-pit formationliquid-phase atomic force microscopyoptical spectroscopyorganic nanocrystalsporphyrinporphyrin protonation

More Related Videos

Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures
09:12

Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures

Published on: August 10, 2017

7.8K
Harvesting Solar Energy by Means of Charge-Separating Nanocrystals and Their Solids
13:29

Harvesting Solar Energy by Means of Charge-Separating Nanocrystals and Their Solids

Published on: August 23, 2012

14.3K

Related Experiment Videos

Last Updated: Oct 25, 2025

Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices
11:06

Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices

Published on: July 8, 2016

10.6K
Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures
09:12

Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures

Published on: August 10, 2017

7.8K
Harvesting Solar Energy by Means of Charge-Separating Nanocrystals and Their Solids
13:29

Harvesting Solar Energy by Means of Charge-Separating Nanocrystals and Their Solids

Published on: August 23, 2012

14.3K

Area of Science:

  • Materials Science
  • Electrochemistry
  • Nanotechnology

Background:

  • Organic nanocrystal dissolution is influenced by pH and molecular chemistry.
  • Free-base porphyrin nanocrystals dissolve in acidic solutions via protonation.
  • Metal porphyrin nanocrystals are stable in acidic conditions.

Purpose of the Study:

  • To investigate if electrochemistry can induce dissolution in both free-base and metal porphyrin nanocrystals.
  • To explore the real-time dissolution mechanisms of porphyrin nanocrystals under electrochemical control.

Main Methods:

  • Electrochemical atomic force microscopy (EC-AFM) was employed for in situ monitoring.
  • Real-time observation of nanocrystal dissolution upon reaching oxidation potential.

Main Results:

  • Both free-base and metal porphyrin nanocrystals undergo dissolution when their oxidation potential is reached.
  • Dissolution occurs via different regimes depending on the applied electrochemical potential.
  • Metal porphyrin nanocrystals, unlike in acidic solutions, show electrochemical susceptibility.

Conclusions:

  • Electrochemistry is a viable strategy to control the dissolution of diverse porphyrin nanocrystals.
  • The electron-rich π-structure of porphyrins facilitates electrochemical oxidation and subsequent dissolution.
  • EC-AFM provides critical insights into the in situ electrochemical dissolution dynamics of organic nanocrystals.