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Related Experiment Videos

Vancomycin entry into lung lymph in sheep.

D G May1, C W Stratton, W D Denney

  • 1Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

Antimicrobial Agents and Chemotherapy
|November 1, 1987
PubMed
Summary
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Vancomycin effectively reaches lung interstitial fluid after intravenous administration, achieving a near-complete distribution. This finding supports vancomycin

Area of Science:

  • Pharmacokinetics and Drug Distribution
  • Pulmonary Medicine
  • Infectious Diseases

Background:

  • Antibiotic distribution to target tissues is vital for effective treatment.
  • Understanding vancomycin's penetration into lung interstitial fluid is crucial for treating pulmonary infections.

Purpose of the Study:

  • To estimate the concentration of systemically administered vancomycin in lung interstitial fluid.
  • To assess the therapeutic potential of vancomycin for pulmonary infections.

Main Methods:

  • Utilized a sheep model with a chronic pulmonary lymph fistula.
  • Collected simultaneous plasma and pulmonary lymph specimens over 6 hours post-intravenous vancomycin (7 mg/kg) administration.

Main Results:

Related Experiment Videos

  • Vancomycin demonstrated complete distribution into pulmonary lymph after a slight delay.
  • The ratio of free vancomycin in lymph to free vancomycin in plasma was 0.9.

Conclusions:

  • Vancomycin achieves excellent concentrations in the lung interstitial fluid.
  • Vancomycin is a suitable therapeutic option for treating pulmonary infections caused by susceptible microorganisms.