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Updated: Oct 25, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Pharmacotherapy in Childhood Obesity
Peter Kühnen1, Heike Biebermann1, Susanna Wiegand2
1Institute for Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Background:
The increasing number of obese children and adolescence is a major problem in health-care systems. Currently, the gold standard for the treatment of these patients with obesity is a multicomponent lifestyle intervention. Unfortunately, this strategy is not leading to a substantial and long-lasting weight loss in the majority of patients. This is the reason why there is an urgent need to establish new treatment strategies for children and adolescents with obesity to reduce the risk for the development of any comorbidities like cardiovascular diseases or diabetes mellitus type 2.
Summary:
In this review, we outline available pharmacological therapeutic options for children and compare the available study data with the outcome of conservative treatment approaches.
Key Messages:
We discussed, in detail, how knowledge about underlying molecular mechanisms might support the identification of effective antiobesity drugs in the future and in which way this might modulate current treatment strategies to support children and adolescence with obesity to lose body weight.
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