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Updated: Oct 25, 2025

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In Vitro Strategies to Vascularize 3D Physiologically Relevant Models.

Alessandra Dellaquila1,2,3, Chau Le Bao1,4, Didier Letourneur1

  • 1Université de Paris, INSERM U1148, X Bichat Hospital, Paris, F-75018, France.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Creating prevascularized 3D tissue models is crucial for regenerative medicine and drug development. This review explores advancements in vascularization techniques for better clinical applications.

Keywords:
3D cell culturebioprintingmicrofluidicstissue engineeringvascularization

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Vascularization of 3D models is a significant hurdle in tissue engineering, impacting clinical and industrial use.
  • Prevascularized models offer improved integration and more physiologically relevant platforms compared to current methods.

Purpose of the Study:

  • To review recent advancements in prevascularization techniques for 3D tissue models.
  • To discuss the application of natural and synthetic materials in creating organ-specific models.
  • To present challenges, future directions, and clinical translation of vascularized constructs.

Main Methods:

  • Review of microfluidic technology for vascularization.
  • Analysis of 3D coculture models (spheroids, organoids).
  • Evaluation of biofabrication strategies for vascularized constructs.

Main Results:

  • Numerous strategies exist for fabricating vascularized 3D constructs.
  • Natural and synthetic materials are increasingly used for organ-specific models.
  • Progress has been made in developing perfusable tissue platforms.

Conclusions:

  • Combining complementary strategies is key to advancing vascularized tissue models.
  • These models hold significant promise for regenerative medicine and drug development.
  • Overcoming current drawbacks will facilitate clinical and industrial translation.