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Updated: Oct 25, 2025

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Synthesis of Organosulfur and Related Heterocycles under Mechanochemical Conditions
Tanmay Chatterjee1, Brindaban C Ranu2
1Department of Chemistry, Birla Institute of Technology and Science, Pilani (BITS Pilani), Hyderabad Campus, Jawahar Nagar, Hyderabad 500078, Telangana, India.
Abstract:
In the last few decades, ball-milling has received tremendous attention as a "green tool" for conducting various challenging organic transformations under transition-metal-free and solvent-free conditions. Organosulfur and related heterocycles are ubiquitous in numerous biologically active molecules with potential applications, and those molecules could be synthesized from readily available starting materials under mechanochemical conditions without using any hazardous chemical or solvent. This synopsis highlights the green strategies developed in recent times to synthesize organosulfur and related heterocycles under ball-milling conditions.
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