Related Experiment Video
Updated: Oct 25, 2025
08:56
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
9.3K
Thyroid hypofunction in aging testicular cancer survivors
Ragnhild V Nome1,2, Milada Cvancarova Småstuen3, Sophie D Fosså2,4
1Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Acta Oncologica (Stockholm, Sweden)
|August 5, 2021
Summary
Testicular cancer survivors have a nearly doubled risk of thyroid hypofunction compared to the general population, even decades after treatment. Regular thyroid hormone monitoring is recommended for these survivors.
Area of Science:
- Endocrinology
- Oncology
- Public Health
Background:
- Thyroid hypofunction is a known late effect in cancer survivors.
- Previous research has not deeply evaluated this in testicular cancer survivors (TCSs).
Purpose of the Study:
- To investigate the prevalence of thyroid hypofunction in long-term TCSs.
- To compare these findings with a general population control group.
Main Methods:
- A cohort of 1,436 Norwegian TCSs diagnosed between 1980-1994 was studied.
- Thyroid hypofunction was defined by serum thyrotropin levels and levothyroxine prescription.
- Data were compared with the HUNT3 Survey general population health data.
Main Results:
- Three decades post-diagnosis, 11% of TCSs exhibited thyroid hypofunction.
- TCSs showed a 1.9-fold increased prevalence of thyroid hypofunction compared to controls.
- Treatment modality did not significantly impact the risk of thyroid hypofunction.
Conclusions:
- TCSs demonstrate a higher prevalence of thyroid hypofunction than the general population.
- Hypothyroidism in TCSs may exacerbate risks of hypogonadism and cardiovascular disease.
- Routine thyroid hormone monitoring is advisable for testicular cancer survivors.
Related Concept Videos
01:18Functions of Thyroid Hormones
3.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.8K
01:23The Thyroid Gland
5.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
5.1K
01:28Menopause
2.6K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
2.6K
01:20Synthesis and Regulation of Thyroid Hormones
5.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.9K
01:20Disorders of the Male Reproductive System
3.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.0K
01:27Adrenal Gland Disorders
2.3K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.3K