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CorNeat KPro: Ocular Implantation Study in Rabbits
Gilad Litvin1, Ido Klein1, Yoav Litvin2
1CorNeat Vision Ltd, Raanana, Israel.
Cornea
|August 5, 2021
Summary
The novel CorNeat Keratoprosthesis (KPro) synthetic cornea demonstrated surgical feasibility and successful biointegration in rabbits, showing promising results for treating corneal blindness.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Corneal blindness affects millions globally, necessitating innovative solutions.
- The CorNeat Keratoprosthesis (KPro) offers a synthetic alternative for corneal reconstruction.
- Biointegration of synthetic implants is crucial for long-term efficacy.
Purpose of the Study:
- To assess the surgical feasibility of the CorNeat Keratoprosthesis (KPro).
- To evaluate the long-term tissue integration of the synthetic cornea in a rabbit model.
- To determine the safety and inflammatory response associated with the KPro implant.
Main Methods:
- Unilateral implantation of the CorNeat KPro in eight New Zealand White rabbits.
- Six-month follow-up with regular ophthalmological monitoring via slit-lamp biomicroscopy.
- Histopathological analysis of enucleated eyes to evaluate tissue integration and inflammation.
Main Results:
- The CorNeat KPro implantation was surgically feasible with an 87.5% retention rate at 6 months.
- Minimal inflammation observed, with no retroprosthetic membrane formation.
- Histology confirmed biointegration, showing fibroblast and collagen infiltration within the KPro skirt.
Conclusions:
- The CorNeat Keratoprosthesis (KPro) demonstrated successful integration and feasibility in rabbit eyes.
- The synthetic cornea shows potential for clinical application in treating corneal blindness.
- Further research is warranted to translate these findings to human patients.
